1,5,6,7-Tetrahydro-4H-indol-4-one → 1,5,6,7-Tetrahydro-indol-4-one oxime

HRID 1452031

반응식

HRID 1452031 반응식
C([O-])(=O)C.[Na+].Cl.[NH2:7][OH:8].O=[C:10]1[CH2:18][CH2:17][CH2:16][C:15]2[NH:14][CH:13]=[CH:12][C:11]1=2>O.C(O)C>[N:7](=[C:10]1[CH2:18][CH2:17][CH2:16][C:15]2[NH:14][CH:13]=[CH:12][C:11]1=2)[OH:8]

참가 물질

6

반응물 3

HCID 2802291,5,6,7-Tetrahydro-4H-indol-4-oneHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

생성물 1

HCID 9156771,5,6,7-Tetrahydro-indol-4-one oxime

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A solution of 6.08 g of sodium acetate, 5.15 g of hydroxylamine hydrochloride, and 5.25 g of 4-keto-4,5,6,7-tetrahydro indole in 12 mL of water and 36 mL of ethanol was heated at 50° C. for 3 hr, quenched in water, extracted with ethyl acetate and dried over magnesium sulfate. The solvents were removed in vacuo to give a mixture of oxime isomers which was characterized by NMR and Mass spectroscopy.

후처리

  1. customquenched in water
  2. extractionextracted with ethyl acetate
  3. dry with materialdried over magnesium sulfate
  4. customThe solvents were removed in vacuo
  5. customto give

출처 및 근거

ORD 기록
ord-67f58450e7b44dd5893acb47d5bfeea7
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05606054

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