Ketamine → Esmolol

HRID 1454323

반응식

HRID 1454323 반응식
[CH:1]1C=CC(SC[C@H]2O[C@@H](N3C4=NC=NC(N[C@H]5[C@H](O)CCC5)=C4N=C3)[C@H](O)[C@@H]2O)=C(F)C=1.CNC1(C2C=CC=CC=2Cl)C(=O)CCCC1.CC1C=CC=C(C)C=1NC1SCCCN=1.CC(C1C=CC2SC3C=CC=CC=3N(CCCN(C)C)C=2C=1)=O.[CH:87](/[C:92](O)=O)=[CH:88]/[C:89]([OH:91])=[O:90].[CH3:95][CH:96]([NH:98][CH2:99][CH:100]([OH:113])[CH2:101][O:102][C:103]1[CH:104]=[CH:105]C(CCOC)=[CH:107][CH:108]=1)[CH3:97].CC(NCC(O)COC1C=CC=C2C=CC=CC=12)C>CS(C)=O>[CH3:97][CH:96]([NH:98][CH2:99][CH:100]([OH:113])[CH2:101][O:102][C:103]1[CH:104]=[CH:105][C:92]([CH2:87][CH2:88][C:89]([O:91][CH3:1])=[O:90])=[CH:107][CH:108]=1)[CH3:95]

참가 물질

8

반응물 6

HCID 3821KetamineHCID 4171MetoprololHCID 4946PropranololHCID 5707XylazineHCID 6420038Acepromazine MaleateHCID 11561692Gs-9667

생성물 1

HCID 59768Esmolol

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

Rats (Sprague Dawley) weighing 300-400 gms were purchased from Simonsen laboratories. CVT-3619 was dissolved in DMSO and further diluted in saline. CVT-510 was dissolved in saline. Ketamine was purchased from Fort Dodge Animal Health, Xylazine from Bayer and Acepromazine Maleate from Fermenta Animal Health Co. Metoprolol and propranolol were purchased from SIGMA. Esmolol was obtained from a local pharmacy.

후처리

  1. additionfurther diluted in saline
  2. dissolutionCVT-510 was dissolved in saline

출처 및 근거

ORD 기록
ord-4b75149209604688b19e1400bc412ecb
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07479485B2

연결된 노트

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