1,2,3,6-Tetrahydropyridine → 1-(6-(2-Butynyloxy)-5-fluoropyrimidin-4-yl)-1,2,3,6-tetrahydropyridine

반응식

[CH2:1]([O:5][C:6]1[C:11]([F:12])=[C:10](Cl)[N:9]=[CH:8][N:7]=1)[C:2]#[C:3][CH3:4].[NH:14]1[CH2:19][CH:18]=[CH:17][CH2:16][CH2:15]1>>[CH2:1]([O:5][C:6]1[N:7]=[CH:8][N:9]=[C:10]([N:14]2[CH2:15][CH:16]=[CH:17][CH2:18][CH2:19]2)[C:11]=1[F:12])[C:2]#[C:3][CH3:4]

참가 물질

반응물 2

HCID 127501,2,3,6-Tetrahydropyridine

HCID 225997174-(2-Butynyloxy)-5-fluoro-6-chloropyrimidine

생성물 1

HCID 593411481-(6-(2-Butynyloxy)-5-fluoropyrimidin-4-yl)-1,2,3,6-tetrahydropyridine수율 101.4%

실험 절차

0.2 g of 4-(2-butynyloxy)-6-chloro-5-fluoropyrimidine and 0.25 g of 1,2,3,6-tetrahydropyridine were mixed and left for 3 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.25 g of 1-(6-(2-butynyloxy)-5-fluoropyrimidin-4-yl)-1,2,3,6-tetrahydropyridine (hereinafter, referred to as Compound (53)).

출처 및 근거

ORD 기록: ord-83ad6d2e8682477ebd923d867eee68c3
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07732448B2

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