Carbon tetrabromide → 5-Bromo-2-(2-thienylmethoxy)benzyl bromide

HRID 1455968노트

반응식

HRID 1455968 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[C:6]([CH:9]=1)[CH2:7]O.C(Br)(Br)(Br)[Br:18].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>ClCCl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[C:6]([CH:9]=1)[CH2:7][Br:18]

참가 물질

5

반응물 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 289814405-Bromo-2-(2-thienylmethoxy)benzenemethanol

생성물 1

HCID 221055055-Bromo-2-(2-thienylmethoxy)benzyl bromide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 5-bromo-2-(2-thienylmethoxy)benzyl alcohol (0.53 g, 1.77 mmoles) in dichloromethane (12 ml) was cooled in an ice bath and treated with carbon tetrabromide (0.73 g, 2.2 mmol) polymer bound triphenylphosphine (0.65 g, 1.95 mmol) and stirred at ambient temperature for 42 hours. The reaction was filtered and evaporated. Chromatography (eluant: ethyl acetate/hexane) gave 5-bromo-2-(2-thienylmethoxy)benzyl bromide as a white solid (0.29, 45%).

후처리

  1. filtrationThe reaction was filtered
  2. customevaporated

출처 및 근거

ORD 기록
ord-994f6e71f46847b498bd0647c996af81
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05843942

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