Methyl iodide → N,N-diethyl 2-chloro-6-methylbenzamide

HRID 1458089

반응식

HRID 1458089 반응식
[CH2:1]([N:3]([CH2:13][CH3:14])[C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:2].[CH3:15]I>>[CH2:13]([N:3]([CH2:1][CH3:2])[C:4](=[O:12])[C:5]1[C:10]([CH3:15])=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:14]

참가 물질

3

반응물 2

HCID 6328Methyl iodideHCID 825662-Chloro-N,N-diethylbenzamide

생성물 1

HCID 18630133N,N-diethyl 2-chloro-6-methylbenzamide수율 92%

실험 절차

The compound from example e (1.0 eq) and MeI (3.0 eq) were combined according to Method A. The crude product was purified by HPLC with 1:4 EtOAc/hexanes to give 5.2 g of N,N-diethyl 2-chloro-6-methylbenzamide as a yellow solid, a 92% yield. m.p. 48°-49° C.

후처리

  1. customThe crude product was purified by HPLC with 1:4 EtOAc/hexanes

출처 및 근거

ORD 기록
ord-1a099b53b9b94e53a44f57914085fbd0
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05849723

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