Hydrochloric Acid → HCID 54321377, 화합물

HRID 1458571노트

반응식

[OH-].[Na+].[Cl:3][C:4]1[C:5]([N:19](S(C)(=O)=O)[S:20]([CH3:23])(=[O:22])=[O:21])=[C:6]2[C:11](=[CH:12][C:13]=1[Cl:14])[N:10]=[C:9]([O:15][CH3:16])[C:8]([O:17][CH3:18])=[N:7]2.Cl>>[Cl:3][C:4]1[C:5]([NH:19][S:20]([CH3:23])(=[O:22])=[O:21])=[C:6]2[C:11](=[CH:12][C:13]=1[Cl:14])[N:10]=[C:9]([O:15][CH3:16])[C:8]([O:17][CH3:18])=[N:7]2

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 14798Sodium Hydroxide

HCID 54103043HCID 54103043, 화합물

생성물 1

HCID 54321377HCID 54321377, 화합물수율 84%

실험 절차

Aqueous sodium hydroxide (1M, 145 ml, 145 mmol) was added to a suspension of 6,7-dichloro-5-di(methanesulphonyl)amino-2,3-dimethoxyquinoxaline (from step (a), 12.28 g, 28.6 mmol) and the mixture was stirred at room temperature for 16 hours. The resulting orange solution was treated with 2M hydrochloric acid (to pH3) and the solid which precipitated was filtered off, washed with water and ether, and dried in vacuo at 80° C. to give N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)methanesulphonamide (8.46 g, 84%) as a white solid, m.p. 225°-227° C.

후처리

customthe solid which precipitated
filtrationwas filtered off
washwashed with water and ether
customdried in vacuo at 80° C.

출처 및 근거

ORD 기록: ord-8d770f62e6524feb864f26d52013763e
출처 데이터셋: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05852016

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