2-Chlorophenol → 4-(2-Chlorophenoxy)butanoic acid

HRID 14598

반응식

HRID 14598 반응식
[Na].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9].[O:10]1[CH2:14][CH2:13][CH2:12][C:11]1=[O:15]>C(O)C>[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH2:14][CH2:13][CH2:12][C:11]([OH:15])=[O:10]

참가 물질

5

반응물 3

HCID 72452-ChlorophenolHCID 7302Gamma-ButyrolactoneHCID 5360545Sodium

생성물 1

HCID 30143434-(2-Chlorophenoxy)butanoic acid수율 80.4%

시약·촉매·용매 1

HCID 702Ethanol용매2회

반응 조건

온도
150 °C

실험 절차

To a solution of sodium (405 mg, 1.08 mmol) in ethanol (11.1 mL) was added 2-chlorophenol and the reaction mixture was stirred for 5 minutes before adding dihydro-furan-2-one (1.4 g, 16.1 mmol). The reaction mixture was stirred for 5 hours at 100° C. after which time the ethanol was slowly evaporated by continuous heating to 150° C. for another 12 hours. After such time the residue was dissolved in water (7 mL) and aqueous hydrochloric acid (1N) was added until precipitation occurred. The precipitate was isolated by filtration, washed with water and dried in vacuo to yield the title compound as yellow solid (2.79 g, 80.4%).

후처리

  1. customwas slowly evaporated
  2. dissolutionAfter such time the residue was dissolved in water (7 mL)
  3. additionaqueous hydrochloric acid (1N) was added until precipitation
  4. customThe precipitate was isolated by filtration
  5. washwashed with water
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-cc003b4b1f0546ffbf7061ce23672dbe
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732452B2

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