Hydrochloric Acid → (5-Methyl-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-3-yl)methanone

HRID 1461492노트

반응식

HRID 1461492 반응식
Cl.[C:2](Cl)(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[N:5][CH:4]=1.[CH3:11][CH:12]1[NH:16][N:15]=[CH:14][CH2:13]1.C(N(CC)CC)C>C(Cl)(Cl)Cl>[N:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([N:16]2[CH:12]([CH3:11])[CH2:13][CH:14]=[N:15]2)=[O:9])[CH:4]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 82604Nicotinoyl chlorideHCID 5497805-methyl-4,5-dihydro-1H-pyrazole

생성물 1

HCID 3078468(5-Methyl-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-3-yl)methanone

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Hydrochloride of nicotinic acid chloride (4 g) was suspended in 20 ml of chloroform followed by addition of a mixture of 1.7 g of 5-methyl-2-pyrazoline and 4 g of triethylamine, washing with water and concentration. The product was purified by chromatography on a silica gel column (chloroform/methanol=100/1). Yield; 3.4 g.

후처리

  1. washwashing with water and concentration
  2. customThe product was purified by chromatography on a silica gel column (chloroform/methanol=100/1)

출처 및 근거

ORD 기록
ord-5615206474d841d69cade3b6d5e6fd52
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05075449

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