Carbon Dioxide → 3-Isopropenyl-2-methylene-1-methyl-cyclopentanecarboxylic acid

HRID 1461956노트

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HRID 1461956 반응식
[Mg].[CH3:2][C:3]1[CH2:7][CH2:6][CH:5]([C:8]([CH3:10])=[CH2:9])[C:4]=1[CH2:11]Cl.[C:13](=[O:15])=[O:14].Cl.[Na]>O1CCCC1.CCOCC>[C:8]([CH:5]1[CH2:6][CH2:7][C:3]([CH3:2])([C:13]([OH:15])=[O:14])[C:4]1=[CH2:11])([CH3:10])=[CH2:9]

참가 물질

8

반응물 5

HCID 280Carbon Dioxide2회HCID 313Hydrochloric AcidHCID 5360545SodiumHCID 5462224MagnesiumHCID 142178772-(Chloromethyl)-1-methyl-3-(prop-1-en-2-yl)cyclopent-1-ene

생성물 1

HCID 204542503-Isopropenyl-2-methylene-1-methyl-cyclopentanecarboxylic acid수율 66%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매2회

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온도
-10 °C

실험 절차

75 ml of dry tetrahydrofuran and 23 g of magnesium shavings are added to a round flask which is fitted with a stirrer, thermometer, dropping funnel and reflux condenser. Without stirring there is added thereto slowly (within 4 hours) a solution of 112.4 g of 1-methyl-2-chloromethyl-3-(prop-1-en-2-yl)-cyclopent-1-ene in 100 ml of tetrahydrofuran. The mixture is brought to 60°-65° for 1 hour and then cooled to -10°. A carbon dioxide stream is conducted through the solution, which is cooled to -10° C. The amount of carbon dioxide introduced is weighed; it amounts to 29.5 g. The mixture is left to stand at room temperature overnight. The mixture is then cooled to 10° C. and decomposed with 300 ml of a 10% hydrochloric acid solution. The acid solution is extracted with ether, the organic acid formed is taken up as the sodium salt (treatment with 10% sodium hydroxide) from the ether into the aqueous phase, which is washed with ether. After acidifying with 10% orthophosphoric acid, the mixture is extracted with ether and the etherial solution is dried over sodium sulphate. The solvent is evaporated and there are obtained 78.2 g (yield: 66%) of crude 3-isopropenyl-2-methylene-1-methyl-cyclopentanecarboxylic acid, which are recrystallized with hexane.

후처리

  1. customis fitted with a stirrer
  2. temperaturereflux condenser
  3. additionis added
  4. customslowly (within 4 hours)
  5. temperaturecooled to -10°
  6. waitThe mixture is left
  7. waitto stand at room temperature overnight
  8. temperatureThe mixture is then cooled to 10° C.
  9. extractionThe acid solution is extracted with ether
  10. customthe organic acid formed
  11. washis washed with ether
  12. extractionthe mixture is extracted with ether
  13. dry with materialthe etherial solution is dried over sodium sulphate
  14. customThe solvent is evaporated

출처 및 근거

ORD 기록
ord-83bff3f8f3934e06b877b2f8ba86c59a
출처 데이터셋
uspto-grants-1984_07
특허 번호
US04457862

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