Hydrogen Bromide → hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one

HRID 1463112노트

반응식

HRID 1463112 반응식
Cl[C:2]1[C:7](=[O:8])[CH2:6][CH2:5][CH2:4][C:3]=1[CH:9]1[CH2:15][CH2:14][CH2:13][CH2:12][N:11]([CH3:16])[C:10]1=[O:17].Br>C(Cl)(Cl)Cl.C(O)(=O)C>[OH:8][C:7]1[CH:2]=[C:3]([CH:9]2[CH2:15][CH2:14][CH2:13][CH2:12][N:11]([CH3:16])[C:10]2=[O:17])[CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 2

HCID 260Hydrogen BromideHCID 28175763-(2-Chloro-3-oxocyclohex-1-enyl)-hexahydro-1-methylazepin-2-one

생성물 1

HCID 11746121hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 6212Chloroform용매2회

실험 절차

Using chloroform as solvent. A solution of 3-(2-chloro-3-oxocyclohex-1-enyl)-hexahydro-1-methylazepin-2-one (5.12 g) in chloroform (50 ml) was treated with 48% HBr in acetic acid (2 ml). After 12 hours the organic solvent was removed under reduced pressure and the residue triturated with aqueous ammonia to yield the title compound m.p. 192°-3° C. (EtOAc).

후처리

  1. customAfter 12 hours the organic solvent was removed under reduced pressure
  2. customthe residue triturated with aqueous ammonia

출처 및 근거

ORD 기록
ord-dfbbad517cf14e5ca5b7f1b94c99ad8b
출처 데이터셋
uspto-grants-1984_07
특허 번호
US04463177

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