Hydrochloric Acid → PGL-135 hydrochloride

HRID 1463428

반응식

HRID 1463428 반응식
[NH2:1][C:2]([NH2:4])=[S:3].[ClH:5].[CH3:6][C:7]1[C:13](=O)[CH:12]=[C:11]([CH3:15])[C:9](=[O:10])[CH:8]=1>C(O)C>[ClH:5].[NH2:1][C:2]1[S:3][C:12]2[C:11]([CH3:15])=[C:9]([OH:10])[CH:8]=[C:7]([CH3:6])[C:13]=2[N:4]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 87182,5-Dimethyl-4-benzoquinoneHCID 2723790Thiourea

생성물 1

HCID 16078999PGL-135 hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

To 2.24 g of thiourea were added 60 ml of ethanol and 2.5 ml of concentrated hydrochloric acid, followed by stirring. Then a solution of 8.0 g of p-xyloquinone in ethanol (120 ml) was slowly added dropwise thereto. The reaction mixture was stirred at room temperature for 24 hours and then concentrated to about one-half. The crystals thus precipitated were separated by filtering and washed with a small amount of ethanol. Thus 6.80 g of the title compound was obtained in the form of white crystals.

후처리

  1. stirringThe reaction mixture was stirred at room temperature for 24 hours
  2. concentrationconcentrated to about one-half
  3. customThe crystals thus precipitated
  4. customwere separated
  5. filtrationby filtering
  6. washwashed with a small amount of ethanol

출처 및 근거

ORD 기록
ord-e0d467965a884c47b72c6bc6cbe02159
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05300518

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