Acetic Anhydride → (S)-Benzyl (tetrahydro-2,5-dioxo-3-furyl)carbamate

HRID 1464209

반응식

HRID 1464209 반응식
[CH2:1]([O:8][C:9]([NH:11][C@H:12]([C:17]([OH:19])=[O:18])[CH2:13][C:14]([OH:16])=O)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC(=O)C)(=O)C>C(O)(=O)C>[CH2:1]([O:8][C:9]([NH:11][C@@H:12]1[C:17](=[O:18])[O:19][C:14](=[O:16])[CH2:13]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 2723942N-(Benzyloxycarbonyl)aspartic acid

생성물 1

HCID 11128682(S)-Benzyl (tetrahydro-2,5-dioxo-3-furyl)carbamate

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

For example, N-benzyloxycarbonyl-L-aspartic acid is dissolved in a large excess of acetic anhydride, the acetic acid formed by the reaction and the excess acetic anhydride are distilled off under reduced pressure and the effect of any acetic acid remaining in the residue is removed by the addition of an organic solvent to give N-benzyloxycarbonyl-L-aspartic anhydride [J. Am. Chem. Soc., 81, 167-173 (1959)].

후처리

  1. distillationthe excess acetic anhydride are distilled off under reduced pressure
  2. customthe effect of any acetic acid remaining in the residue is removed by the addition of an organic solvent

출처 및 근거

ORD 기록
ord-0d00a997b1df4e23a14cef71c9b78832
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05302743

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