Ethanol → 2-Nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde

HRID 1464611

반응식

HRID 1464611 반응식
C[O:2][CH:3](OC)[C:4]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][CH:13]([NH:16][C:17](=[O:19])[CH3:18])[CH2:12][CH2:11]2)[CH:7]=[CH:6][C:5]=1[N+:20]([O-:22])=[O:21].C=O.C(O)C>Cl.O>[N+:20]([C:5]1[CH:6]=[CH:7][C:8]([N:10]2[CH2:11][CH2:12][CH:13]([NH:16][C:17](=[O:19])[CH3:18])[CH2:14][CH2:15]2)=[CH:9][C:4]=1[CH:3]=[O:2])([O-:22])=[O:21]

참가 물질

6

반응물 3

HCID 702EthanolHCID 712FormaldehydeHCID 190868632-Nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde dimethylacetal

생성물 1

HCID 190868462-Nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde

시약·촉매·용매 2

HCID 313Hydrochloric Acid촉매HCID 962Water용매

실험 절차

0.3 Gram of 2-nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde dimethylacetal, 5 ml of formalin, 1 ml of ethanol and 2 drops of concentrated hydrochloric acid were refluxed by heating. After the reaction was completed, the solvent was removed by evaporation to obtain the residue, then water was added to the residue. The crystals formed were collected by filtration to yield 0.22 g of 2-nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde.

후처리

  1. temperatureby heating
  2. customthe solvent was removed by evaporation
  3. customto obtain the residue
  4. customThe crystals formed
  5. filtrationwere collected by filtration

출처 및 근거

ORD 기록
ord-24500cb7809f4f38bdc83cb7fb68bc53
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05306719

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