Triphenylphosphine → [4-(Benzyloxy)benzyl](triphenyl)phosphonium chloride

HRID 1465482

반응식

HRID 1465482 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][Cl:16])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:17]1([P:23]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C1(C)C=CC=CC=1>[Cl-:16].[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][P+:23]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 700424-Benzyloxybenzyl chloride

생성물 1

HCID 383834[4-(Benzyloxy)benzyl](triphenyl)phosphonium chloride수율 88.1%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a suspension of 1-(benzyloxy)-4-(chloromethyl)benzene (4.890 g, 21.01 mmol) in toluene (25 ml) was added triphenylphosphine (6.617 g, 25.23 mmol). The mixture was heated under reflux for 24 hrs, and cooled to room temperature. The precipitate was collected by filtration, and dried under reduced pressure to give [4-(benzyloxy)benzyl](triphenyl)phosphonium chloride (9.166 g, yield 88.1%) as a white solid.

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 24 hrs
  3. filtrationThe precipitate was collected by filtration
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-813e6d3b514547329678200b2299595c
출처 데이터셋
uspto-grants-2015_04
특허 번호
US08999989B2

연결된 노트

불러오는 중…