Hydrochloric Acid → 1-Aminomethyl-6,7-dimethoxy-isoquinoline-4-carboxylic acid 4-methoxy-benzylamide hydrochloride

HRID 14658

반응식

HRID 14658 반응식
C(OC(=O)[NH:7][CH2:8][C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:21][CH3:22])=[C:16]([O:19][CH3:20])[CH:17]=2)[C:12]([C:23](=[O:34])[NH:24][CH2:25][C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=2)=[CH:11][N:10]=1)(C)(C)C.[ClH:36]>CCOC(C)=O>[ClH:36].[CH3:33][O:32][C:29]1[CH:30]=[CH:31][C:26]([CH2:25][NH:24][C:23]([C:12]2[C:13]3[C:18](=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=3)[C:9]([CH2:8][NH2:7])=[N:10][CH:11]=2)=[O:34])=[CH:27][CH:28]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 68614449[6,7-Dimethoxy-4-(4-methoxy-benzylcarbamoyl)-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester

생성물 1

HCID 686143361-Aminomethyl-6,7-dimethoxy-isoquinoline-4-carboxylic acid 4-methoxy-benzylamide hydrochloride수율 69%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

As described in example 1, a solution of [6,7-dimethoxy-4-(4-methoxy-benzylcarbamoyl)-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester (84 mg) was treated with HCl in EtOAc to give 46 mg (69%) of 1-aminomethyl-6,7-dimethoxy-isoquinoline-4-carboxylic acid 4-methoxy-benzylamide hydrochloride: 1H NMR (DMSO-d6) δ 3.71 (s, 3H), 3.80 (s, 3H), 3.98 (s, 3H), 4.45 (d, 2H, J=6.03 Hz), 4.69-4.72 (m, 2H), 6.90 (d, 211, J=8.64 Hz), 7.32 (d, 2H, J=8.53 Hz), 7.44 (s, 1H), 7.61 (s, 1H), 8.46 (s, 1H), 8.59-8.62 (br s, 3H), 9.25 (t, 1H, J=6.53 Hz); MS: APCI (M−H) calc'd for C21H23N3O4 380.2; found 380.0.

출처 및 근거

ORD 기록
ord-70a1c15a94a04096ab9ae7cc52302064
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732446B1

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