[F:1][C:2]([F:9])([F:8])[C:3](OCC)=O.O.[NH2:11][NH2:12].C(S[C:16]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[N:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)C>C(O)CCC>[C:24]1([C:16]2[N:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:3]([C:2]([F:1])([F:8])[F:9])=[N:12][N:11]=2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1First, 1.8 g of ethyl trifluoroacetate and 50 mL of 1-butanol were put in a three-neck flask, and the air in the flask was replaced by nitrogen. After that, the mixture was stirred at 0° C. for 10 minutes, and 0.397 g of hydrazine monohydrate was dripped to the mixed solution. This mixed solution was stirred at 0° C. for 20 minutes, and then stirred at room temperature for 1 hour to be reacted. After the reaction, 3.0 g of N-[(ethylsulfanyl)phenylmethylidene]aniline was further added to the mixed solution, and the solution was heated and stirred at 120° C. for 5 hours to be reacted. The mixed solution after the reaction was cooled down to room temperature and filtered, so that filtrate was obtained. The obtained filtrate was concentrated to give a solid. This solid was washed with hexane, so that the triazole derivative HCF3ptz was prepared (yield: 26%). The synthesis scheme of Step 1 is shown by (a-2).
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