Hydrochloric Acid → 4-(2-Methyl-benzothiazol-6-yl)-butyric acid
반응식
C[O:2][C:3](=[O:17])[CH2:4][CH2:5][CH2:6][C:7]1[CH:16]=[CH:15][C:10]2[N:11]=[C:12]([CH3:14])[S:13][C:9]=2[CH:8]=1.[OH-].[Na+].Cl>CCO>[CH3:14][C:12]1[S:13][C:9]2[CH:8]=[C:7]([CH2:6][CH2:5][CH2:4][C:3]([OH:17])=[O:2])[CH:16]=[CH:15][C:10]=2[N:11]=1참가 물질
5
실험 절차
Next, to a solution of 4-(2-methyl-benzothiazol-6-yl)-butyric acid methyl ester in EtOH (4 mL) is added aqueous 1M NaOH (4 mL) and the mixture is stirred at room temperature for 2 hours. The solution is acidified to pH 2 with aqueous 1M HCl and is extracted with ethyl acetate. The organic layer is washed with water, brine, dried over magnesium sulfate and filtered. The solvent is removed under reduced pressure to give 4-(2-methyl-benzothiazol-6-yl)-butyric acid. MS 236.3 (M+1).
후처리
- extractionis extracted with ethyl acetate
- washThe organic layer is washed with water, brine
- dry with materialdried over magnesium sulfate
- filtrationfiltered
- customThe solvent is removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-eb87785d7c704ddc9ed50df24a79cd3b
- 출처 데이터셋
- uspto-grants-2015_04
- 특허 번호
- US09006249B2
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