Hydrochloric Acid → 1-Carboxymethyl-cyclopentanecarboxylic acid benzyl ester

HRID 1469658노트

반응식

HRID 1469658 반응식
[CH2:1]([O:8][C:9]([C:11]1([CH2:16][CH:17]=[O:18])[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:19].[Na+].Cl>C1COCC1.[Ag]=O>[CH2:1]([O:8][C:9]([C:11]1([CH2:16][C:17]([OH:19])=[O:18])[CH2:12][CH2:13][CH2:14][CH2:15]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86648214HCID 86648214, 화합물

생성물 1

HCID 216902921-Carboxymethyl-cyclopentanecarboxylic acid benzyl ester

시약·촉매·용매 2

HCID 92152Silver(II) oxide촉매HCID 8028Tetrahydrofuran용매

실험 절차

Next, to a solution of 1-(2-oxo-ethyl)-cyclopentanecarboxylic acid benzyl ester (200 mg, 0.81 mmol) in THF (5 mL) is added silver(II) oxide (201 mg, 1.62 mmol) and aqueous 1M NaOH (0.81 mL of 1.0 N, 0.81 mmol) and the suspension is stirred at room temperature for 18 hours. The mixture is acidified to pH 3 with aqueous 1M HCl and is extracted with ethyl acetate. The organic layer is washed with water, brine, dried over MgSO4 and filtered. The solvent is removed under reduced pressure to furnish 1-carboxymethyl-cyclopentanecarboxylic acid benzyl ester MS 263.3 (M+1).

후처리

  1. extractionis extracted with ethyl acetate
  2. washThe organic layer is washed with water, brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customThe solvent is removed under reduced pressure

출처 및 근거

ORD 기록
ord-c54d147e7bb14f738735090038b28feb
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09006249B2

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