Methyl chloroformate → (s)-2-((Methoxycarbonyl)amino)-2-phenylacetic acid
반응식
[NH2:1][C@@H:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([OH:5])=[O:4].[OH-].[Na+].Cl[C:15]([O:17][CH3:18])=[O:16]>O1CCOCC1.CCOC(C)=O>[CH3:18][O:17][C:15]([NH:1][C@@H:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([OH:5])=[O:4])=[O:16]참가 물질
6
실험 절차
To a solution of (S)-2-amino-2-phenylacetic acid (0.5 g, 3.31 mmol) in dioxane at 0° C. was added NaOH (5.46 g, 10.92 mmol) followed by dropwise addition of methyl chloroformate (0.51 mL, 6.62 mmol) and the solution was warmed to room temperature with stirring over 1 h. Diluted with EtOAc, washed with 1 N HCl, brine, dried (Na2SO4), filtered and removed solvent in vacuo to give the title compound (0.35 g, 1.673 mmol, 51%).
후처리
- washwashed with 1 N HCl, brine
- dry with materialdried (Na2SO4)
- filtrationfiltered
- customremoved solvent in vacuo
출처 및 근거
- ORD 기록
- ord-128ae61b2efe4ac882cad25c598a9e2c
- 출처 데이터셋
- uspto-grants-2015_04
- 특허 번호
- US09006387B2
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