Dimethylformamide → Methyl-(2-nitro-4-pentafluorosulfanyl-phenyl)-amine

HRID 1473932노트

반응식

HRID 1473932 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([F:13])([F:12])([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:14]([O-:16])=[O:15].[H-].[Na+].[CH3:19]N(C=O)C.IC>O>[CH3:19][NH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([F:11])([F:12])([F:13])([F:10])[F:9])=[CH:4][C:3]=1[N+:14]([O-:16])=[O:15]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 459336502-Nitro-4-(pentafluorosulfanyl)aniline

생성물 1

HCID 86725174Methyl-(2-nitro-4-pentafluorosulfanyl-phenyl)-amine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture 4-amino-3-nitro-phenyl sulfur pentafluoride (2.0 g), 60% sodium hydride (oil) (310 mg) and DMF (15 ml) was added dropwise iodomethane (447 μL) while ice-cooling. After that, the mixture was stirred at room temperature for 3 hours. To the reaction mixture was poured water, and the precipitated solid was collected by filtration. The solid was washed with water and dried to give methyl-(2-nitro-4-pentafluorosulfanyl-phenyl)-amine (2.0 g).

후처리

  1. temperaturecooling
  2. filtrationthe precipitated solid was collected by filtration
  3. washThe solid was washed with water
  4. customdried

출처 및 근거

ORD 기록
ord-1011f45e78384871b382fea651a1eb78
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018134B2

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