Tyramine → 4-{2-[4-(3-Nitro-phenyl)-pyrimidin-2-ylamino]-ethyl}-phenol

반응식

Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=2)[CH:5]=[CH:4][N:3]=1.[NH2:17][CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=1>>[N+:14]([C:10]1[CH:9]=[C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:17][CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=3)[N:7]=2)[CH:13]=[CH:12][CH:11]=1)([O-:16])=[O:15]

참가 물질

반응물 2

HCID 5610Tyramine

HCID 249018872-Chloro-4-(3-nitrophenyl)pyrimidine

생성물 1

HCID 586035964-{2-[4-(3-Nitro-phenyl)-pyrimidin-2-ylamino]-ethyl}-phenol

실험 절차

Intermediate 5 was coupled with tyramine following procedure F. LC-MS showed the product had the expected M+H+ of 337. 1H NMR (Varian 300 MHz, DMSO-d6, shifts relative to the solvent peak at 2.49 ppm) (d, 1H) 7.6-6.6 (m, 7H) 6.0 (d, 2H) 4.85 (s, 2H) 4.40 (d, 2H) 3.0 (m, 1H), 2.0 (m, 4H), 1.6 (m, 4H).

출처 및 근거

ORD 기록: ord-4e4ba4184bf14a818288b76f29c1c248
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07732444B2

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