Diisopropylethylamine → HCID 178499453, 화합물

HRID 1478887노트

반응식

HRID 1478887 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][N+:3]=1[O-:13].CCN(C(C)C)C(C)C.[NH2:23][CH2:24][CH2:25][NH:26][C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30]>CC(O)(C)C>[C:29]([O:28][C:27]([NH:26][CH2:25][CH2:24][NH:23][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][N+:3]=1[O-:13])=[O:33])([CH3:32])([CH3:31])[CH3:30]

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 187201N-BOC-ethylenediamineHCID 59464117HCID 59464117, 화합물

생성물 1

HCID 178499453HCID 178499453, 화합물수율 32.2%

시약·촉매·용매 1

HCID 6386tert-Butanol용매

반응 조건

온도
80 °C

실험 절차

To 2-chloro-5-(2-methoxy-2-oxoethyl)pyridine 1-oxide (2.5 g) in t-BuOH (50 mL) was added DIEA (3.4 mL) and tert-butyl 2-aminoethylcarbamate (3.0 g). The resulting reaction mixture was stirred at 80° C. for 2 days. The solvent was then removed and the residue purified by reverse phase chromatography to afford the desired product (1.3 g).

후처리

  1. customThe resulting reaction mixture
  2. customThe solvent was then removed
  3. customthe residue purified by reverse phase chromatography

출처 및 근거

ORD 기록
ord-9a05cae42dcc4389bad0eb0d7c3f570c
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09403850B2

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