Hydrochloric Acid → HCID 71087282, 화합물

HRID 1478904노트

반응식

HRID 1478904 반응식
[Br:1][C:2]1[C:6]2[CH:7]=[N:8][C:9]([C:11]([O:13]C)=[O:12])=[CH:10][C:5]=2[N:4]([CH2:15][CH3:16])[CH:3]=1.Cl>CCO.[OH-].[Na+]>[Br:1][C:2]1[C:6]2[CH:7]=[N:8][C:9]([C:11]([OH:13])=[O:12])=[CH:10][C:5]=2[N:4]([CH2:15][CH3:16])[CH:3]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 67353647HCID 67353647, 화합물

생성물 1

HCID 71087282HCID 71087282, 화합물수율 98%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

반응 조건

온도
80 °C

실험 절차

A mixture of methyl 3-bromo-1-ethyl-1H-pyrrolo[3,2-c]pyridine-6-carboxylate (3A, 3.0 g, 11 mmol) in EtOH (10 ml) and 1N NaOH (10 ml) was stirred at 80° C. for 5 days. The reaction mixture was acidified with 1N HCl, concentrated in vacuo and dried to give 3-bromo-1-ethyl-1H-pyrrolo[3,2-c]pyridine-6-carboxylic acid (3B, 2.8 g, 10 mmol, 98% yield) as a pale brown powder. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.42 (t, J=7.20 Hz, 3 H) 4.49 (q, J=7.33 Hz, 2 H) 8.35 (s, 1 H) 8.65 (s, 1 H) 8.91 (s, 1 H).

후처리

  1. concentrationconcentrated in vacuo
  2. customdried

출처 및 근거

ORD 기록
ord-f6a1385c58a349ec94a3673a7860ee85
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09403819B2

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