Hydrochloric Acid → HCID 89580768, 화합물
반응식
[OH:1][CH2:2][CH2:3][CH:4]([C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12]C)=[O:11])=[CH:8][CH:7]=1)[CH3:5].O.[OH-].[Li+].Cl>CO.O>[OH:1][CH2:2][CH2:3][CH:4]([C:6]1[CH:7]=[CH:8][C:9]([C:10]([OH:12])=[O:11])=[CH:14][CH:15]=1)[CH3:5]참가 물질
6
실험 절차
To the solution of methyl 4-(4-hydroxybutan-2-yl)benzoate (354 mg, 1.7 mmol) in methanol (30 mL) and water (5 mL) was added lithium hydroxide hydrate (150 mg, 3.6 mmol) were added. The mixture was stirred at room temperature for 12 hours. Then the reaction mixture was acidified by hydrochloric acid aqueous solution (1N) to adjust pH=6 and extracted with dichloromethane (10 mL×3). The organic layers were combined and concentrated to give 4-(4-hydroxybutan-2-yl)benzoic acid (290 mg, 88%).
후처리
- additionwere added
- extractionextracted with dichloromethane (10 mL×3)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-9e701b448488466fa216879e84bdec67
- 출처 데이터셋
- uspto-grants-2016_08
- 특허 번호
- US09409865B2
반응 노트
불러오는 중…