Hydrochloric Acid → HCID 178520557, 화합물

HRID 1480471노트

반응식

HRID 1480471 반응식
C(OC[N:9]1[CH:13]=[C:12]([CH2:14][CH2:15][CH2:16][C:17]([NH:19][CH:20]2[CH2:25][CH2:24][N:23]([C:26]([O:28][CH2:29][C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][C:31]=3[Cl:37])=[O:27])[CH2:22][CH2:21]2)=[O:18])[N:11]=[N:10]1)(=O)C(C)(C)C.[OH-].[Na+].Cl>CO>[NH:9]1[CH:13]=[C:12]([CH2:14][CH2:15][CH2:16][C:17]([NH:19][CH:20]2[CH2:25][CH2:24][N:23]([C:26]([O:28][CH2:29][C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][C:31]=3[Cl:37])=[O:27])[CH2:22][CH2:21]2)=[O:18])[N:11]=[N:10]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86722692HCID 86722692, 화합물

생성물 1

HCID 178520557HCID 178520557, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a stirred solution of 2,4-dichlorobenzyl 4-(4-(1-((pivaloyloxy)methyl)-1H-1,2,3-triazol-4-yl)butanamido)piperidine-1-carboxylate (100 mg, 0.180 mmol) in MeOH (1 mL) at RT was added 1M NaOH (0.397 mL, 0.397 mmol). The reaction mixture was allowed to stir for 1 hr. An equivalent of 1M HCl (0.4 ml) was added to neutralise the reaction mixture and the MeOH removed under reduced pressure. The reaction mixture was diluted with EtOAc and water and the organic portion was separated, dried over MgSO4, filtered and concentrated under reduced pressure. Trituration with diethyl ether afforded the title product;

후처리

  1. customthe MeOH removed under reduced pressure
  2. additionThe reaction mixture was diluted with EtOAc and water
  3. customthe organic portion was separated
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e3006bc62710471088f33a5b8e4072b3
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409895B2

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