Water → N-[(thiophen-2-yl)methyl]acetamide

HRID 1484887노트

반응식

HRID 1484887 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH2:7].[C:8](OC(=O)C)(=[O:10])[CH3:9].O>CN(C1C=CN=CC=1)C.C(Cl)Cl>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:7][C:8](=[O:10])[CH3:9]

참가 물질

6

반응물 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 34005(2-Thienylmethyl)amine

생성물 1

HCID 30617N-[(thiophen-2-yl)methyl]acetamide수율 91%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of thiophen-2-ylmethanamine (600 mg, 5.30 mmol), DMAP (130 mg, 1.06 mmol, 0.2 equiv) and acetic anhydride (648 mg, 6.36 mmol, 1.2 equiv) in DCM (20 mL) was stirred at room temperature for 2 h. Water was added and the reaction was extracted with EA. The combined organic layers were dried (Na2SO4), filtered. The filtrate was concentrated to afford the compound N-(thiophen-2-ylmethyl)acetamide (745 mg, 91%). LC-MS (m/z)=156 [M+H]+.

후처리

  1. extractionthe reaction was extracted with EA
  2. dry with materialThe combined organic layers were dried (Na2SO4)
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-eeae402f90424c95bd8e04d2099787ba
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09422271B2

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