1-Octanethiol → 2-chloro-6-octylthiopyridine N-oxide

HRID 1488728

반응식

HRID 1488728 반응식
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[N+:3]=1[O-:9].[CH2:10]([SH:18])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[OH-].[Na+]>CS(C)=O>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([S:18][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[N+:3]=1[O-:9]

참가 물질

5

반응물 3

HCID 81441-OctanethiolHCID 14798Sodium HydroxideHCID 8176732,6-Dichloropyridine N-Oxide

생성물 1

HCID 229063402-chloro-6-octylthiopyridine N-oxide

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

The 2.01 g (0.0122 moles) of 2,6-dichloropyridine N-oxide and 2.10 g (85%) (0.0122 moles) of 1-octylmercaptan was reacted with 0.488 g (0.0122 moles) of ground sodium hydroxide in 8.2 ml of DMSO at 80° C. for 6 hours to give 2-chloro-6-octylthiopyridine N-oxide. It was reacted with 1.47 g (0.0367 moles) of ground sodium, hydroxide at 80° C. for 3 hours to give 1-hydroxy-6-octylthiopyridine-2(1H)-one. After cooling, it was added 180 ml of water and was adjusted with 6N HCL to pH 3. The precipitate was filtered, washed with water and washed with 150 ml of petroleum ether to give 1.34 g (43%).

출처 및 근거

ORD 기록
ord-8beb7781f3b44448a0f3a0ffcbcd05af
출처 데이터셋
uspto-grants-1997_10
특허 번호
US05675013

연결된 노트

불러오는 중…