Propylamine → 2-(n-Decyl)imidazoline

HRID 1488794

반응식

HRID 1488794 반응식
[C:1](#[N:12])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].[Li].[CH2:14]([NH2:17])[CH2:15]C>C(N)CN>[CH2:2]([C:1]1[NH:12][CH2:15][CH2:14][N:17]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

참가 물질

5

반응물 3

HCID 7852Propylamine2회HCID 16722Undecanenitrile2회HCID 3028194Lithium

생성물 1

HCID 114994602-(n-Decyl)imidazoline수율 22%

시약·촉매·용매 1

HCID 3301Ethylenediamine용매2회

실험 절차

Reduction of undecanenitrile in n-propylamine and ethylene-diamine. Lithium, (0.21 g, 30 mmol) in small pieces, was added to a stirred solution of undecanenitrile (0.84 g, 5 mmol) in n-propylamine and ethylenediamine (1.0 mL). The temperature began to rise after 20 min and reached 32° after 30 min and the reaction mixture turned blue. An aliquot of the reaction mixture showed no nitrile by glpc. The reaction mixture was poured over crushed ice and extracted with ethyl acetate (2×50 mL). After distillation of the ethyl acetate the residue deposited crystals. The crystals were collected and dried to give 2-(n-decyl)imidazoline (0.23 g, 22%)

후처리

  1. waitreached 32° after 30 min
  2. additionThe reaction mixture was poured
  3. customover crushed ice
  4. extractionextracted with ethyl acetate (2×50 mL)
  5. distillationAfter distillation of the ethyl acetate the residue
  6. customThe crystals were collected
  7. customdried

출처 및 근거

ORD 기록
ord-e673198c27d0401f99ebe5ce08e77232
출처 데이터셋
uspto-grants-1997_10
특허 번호
US05675038

연결된 노트

불러오는 중…