Diisopropylethylamine → 2-Phenyl-5,6-dihydro-1,2,4-triazolo[4,3-c]quinazolin-3-one

HRID 1489031노트

반응식

HRID 1489031 반응식
Cl[C:2]1[N:11]2[C:12](=[O:21])[N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:14]=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.C(N(CC)C(C)C)(C)C>C(O)C.C(Cl)(Cl)Cl.[Pd]>[C:15]1([N:13]2[C:12](=[O:21])[N:11]3[CH2:2][NH:3][C:4]4[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=4[C:10]3=[N:14]2)[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

참가 물질

6

반응물 2

HCID 81531DiisopropylethylamineHCID 15428837HCID 15428837, 화합물

생성물 1

HCID 1354844832-Phenyl-5,6-dihydro-1,2,4-triazolo[4,3-c]quinazolin-3-one

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 6212Chloroform용매

실험 절차

A mixture of 5-chloro-2-phenyl-1,2,4-triazolo[4,3-c]-quinazolin-3-one (1 g, 3.4 mmol), N,N-diisopropylethylamine (1 ml, 6.7 mmol) and 10% Pd-C (200 mg) in ethanol was shaken under hydrogen at 50 psi overnight. The reaction was diluted with CHCl3 and filtered through Celite. The filtrate was evaporated under reduced pressure and the residue dissolved in dichloromethane. The solution was washed with water, dried over Na2 SO4 and evaporated under reduced pressure to yield 2-phenyl-5,6-dihydro-1,2,4-triazolo[4,3-c]quinazolin-3-one (Compound 2) as a white solid. m.p. 202°-204° C.

후처리

  1. filtrationfiltered through Celite
  2. customThe filtrate was evaporated under reduced pressure
  3. dissolutionthe residue dissolved in dichloromethane
  4. washThe solution was washed with water
  5. customdried over Na2 SO4
  6. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-781b4b12552c485a9b2e55a82612fc99
출처 데이터셋
uspto-grants-1997_10
특허 번호
US05677309

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