1,2-Dichloroethane → 4-chloro-N-phenethylbenzenesulfonamide

HRID 1490364노트

반응식

HRID 1490364 반응식
C(Cl)CCl.[C:5]1([CH2:11][CH2:12][NH2:13])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[OH-].[Na+].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.O>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([S:23]([NH:13][CH2:12][CH2:11][C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)(=[O:25])=[O:24])=[CH:19][CH:18]=1

참가 물질

7

반응물 4

HCID 111,2-DichloroethaneHCID 1001PhenethylamineHCID 73984-Chlorobenzenesulfonyl chlorideHCID 14798Sodium Hydroxide

생성물 1

HCID 7228614-chloro-N-phenethylbenzenesulfonamide

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 962Water용매

실험 절차

To a mixture of 150 ml of ethylene chloride and 150 ml of water are added 30.3 g of 2-phenylethylamine, 12 g of sodium hydroxide and 0.5 g of tetrabutylammonium bromide. 65.5 g of 4-chlorobenzenesulphonic acid chloride are added to the mixture in batches with stirring. After 30 minutes the organic phase is separated off, evaporated down and the residue is recrystallised from toluene.

후처리

  1. customAfter 30 minutes the organic phase is separated off
  2. customevaporated down
  3. customthe residue is recrystallised from toluene

출처 및 근거

ORD 기록
ord-67782c2be1ce455088bebafa349fdd7c
출처 데이터셋
uspto-grants-1997_10
특허 번호
US05681961

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