Water → N-(4-hydroxynaphthalen-1-yl)acetamide

HRID 1492127

반응식

HRID 1492127 반응식
O.[NH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([OH:13])=[CH:5][CH:4]=1.[C:14](OC(=O)C)(=[O:16])[CH3:15]>C(O)C>[OH:13][C:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]([NH:2][C:14](=[O:16])[CH3:15])=[CH:4][CH:5]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 178151-Amino-4-naphthol

생성물 1

HCID 235848N-(4-hydroxynaphthalen-1-yl)acetamide수율 79.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Into a 500 ml round bottom flask (fitted with a magnetic stirrer), a 50:50 mixture of water:ethanol was combined with 4-amino1-naphthol (20 g, 125 mmole) until the solid was completely dissolved. The solution was warmed to boiling, and to it was added acetic anhydride (14 g) and the resulting solution was stirred for 1 hour. Upon cooling, crystals of N-(4-hydroxy-1-naphthyl)acetamide (20 g, 79% yield) formed.

후처리

  1. customInto a 500 ml round bottom flask (fitted with a magnetic stirrer)
  2. dissolutionwas completely dissolved
  3. temperatureThe solution was warmed
  4. temperatureUpon cooling

출처 및 근거

ORD 기록
ord-9d36a4eb96e4449bbcd6f139e87e7d73
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05372931

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