3-(Trifluoromethyl)phenol → HCID 21471060, 화합물

HRID 1492366

반응식

HRID 1492366 반응식
Cl[C:2]1[CH:7]=[C:6]([S:8][CH3:9])[CH:5]=[C:4](Cl)[N:3]=1.[OH:11][C:12]1[CH:13]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:16][CH:17]=1.[H-].[Na+]>>[F:21][C:18]([F:19])([F:20])[C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=1)[O:11][C:2]1[CH:7]=[C:6]([S:8][CH3:9])[CH:5]=[C:4]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:19])([F:20])[F:21])[CH:13]=2)[N:3]=1

참가 물질

4

반응물 3

HCID 73763-(Trifluoromethyl)phenolHCID 24758Sodium hydrideHCID 189502312,6-Dichloro-4-(methylthio)pyridine

생성물 1

HCID 21471060HCID 21471060, 화합물수율 85.3%

실험 절차

A mixture of 2,6-dichloro-4-methylthiopyridine (0.97 g; 0.005 mol), 3-hydroxybenzotrifluoride (1.3 ml; 10.4 mmol) and sodium hydride (0.2 g) was reacted and worked up according to the procedure of Example 1 above to give 2,6-di-(3-trifluoromethyl phenoxy)-4-methylthiopyridine (1.9 g; 85%)

후처리

  1. customwas reacted

출처 및 근거

ORD 기록
ord-aa934b7d69004c628c57501ce6524b0d
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05374604

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