반응식
[CH3:1][C:2](=[N:4][OH:5])[CH3:3].Cl[CH:7]([C:9]1[CH:14]=[CH:13][C:12]([S:15][C:16]2[CH:17]=[C:18]([C:23]3([O:29][CH3:30])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[CH:19]=[C:20]([F:22])[CH:21]=2)=[CH:11][CH:10]=1)[CH3:8]>>[F:22][C:20]1[CH:19]=[C:18]([C:23]2([O:29][CH3:30])[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[CH:17]=[C:16]([S:15][C:12]2[CH:11]=[CH:10][C:9]([CH:7]([O:5][N:4]=[C:2]([CH3:3])[CH3:1])[CH3:8])=[CH:14][CH:13]=2)[CH:21]=1참가 물질
3
반응 조건
- 온도
- 60 °C
실험 절차
Using an analogous procedure to that described in Example 1 except that the reactants were heated to 60° C. for 2 hours, acetone oxime was reacted with 4-{3-[4-(1-chloroethyl)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran to give acetone O-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio)-α-methylbenzyl}oxime as an oil in 58% yield.
출처 및 근거
- ORD 기록
- ord-eb32913a49604aa78cf550693e028e28
- 출처 데이터셋
- uspto-grants-1994_12
- 특허 번호
- US05376680
연결된 노트
불러오는 중…