Hydrochloric Acid → 3-(Dimethylamino)-1-(thiophen-2-yl)propan-1-one hydrochloride

HRID 1493581

반응식

HRID 1493581 반응식
[C:1]([C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)(=[O:3])[CH3:2].[ClH:9].[CH3:10][NH:11][CH3:12].[CH2:13]=O.Cl>C(O)C.CC(C)=O>[ClH:9].[CH3:10][N:11]([CH3:13])[CH2:12][CH2:2][C:1]([C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)=[O:3]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 69202-AcetylthiopheneHCID 10473Dimethylamine, hydrochloride

생성물 1

HCID 28768913-(Dimethylamino)-1-(thiophen-2-yl)propan-1-one hydrochloride수율 155.1%

시약·촉매·용매 2

HCID 180Acetone용매HCID 702Ethanol용매2회

실험 절차

A mixture of 2-acetylthiophene (63.1 g, 0.5 mol), dimethylamine hydrochloride (53.0 g, 0.65 mol), paraformaldehyde (19.8 g, 0.22 mol), and 12N hydrochloric acid (1 ml) in ethanol (80 ml) was refluxed for one and one-half hours. The solution was diluted with ethanol (100 ml) and acetone (500 ml). The solution was chilled overnight and the resulting solid was collected by filtration to yield 75.0 g (73%) of 3-dimethylamino-1-(2-thienyl)-1-propanone hydrochloride as a colorless crystalline solid. mp =182° C.-184° C.

후처리

  1. temperaturewas refluxed for one and one-half hours
  2. temperatureThe solution was chilled overnight
  3. filtrationthe resulting solid was collected by filtration

출처 및 근거

ORD 기록
ord-84ab1556f112429aa3c3af0c90e4d4a4
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05023269

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