Hydrochloric Acid → 8-(4-Chloro-benzenesulfonylamino)-4-(2-imidazol-1-yl-ethyl)-octanoic acid

HRID 1494100노트

반응식

HRID 1494100 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH:16]([CH2:23][CH2:24][N:25]2[CH:29]=[CH:28][N:27]=[CH:26]2)[CH2:17][CH2:18][C:19]([O:21]C)=[O:20])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[OH-].[Na+].Cl>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH:16]([CH2:23][CH2:24][N:25]2[CH:29]=[CH:28][N:27]=[CH:26]2)[CH2:17][CH2:18][C:19]([OH:21])=[O:20])(=[O:10])=[O:9])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 10094868Methyl 8-(p-chlorophenylsulfonamido)-4-[2-(1-imidazolyl)ethyl]-octanoate

생성물 1

HCID 100255698-(4-Chloro-benzenesulfonylamino)-4-(2-imidazol-1-yl-ethyl)-octanoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 0.117 g of methyl 8-(p-chlorophenylsul- fonamido)-4-[2-(1-imidazolyl)ethyl]-octanoate in 3 mL methanol is mixed with 0.55 mL 1N sodium hydroxide. The mixture is heated at 50° for 4 hours. The reaction mixture is neutralized with 0.55 mL 1N hydrochloric acid and the solvent is evaporated. The residue is triturated with methylene chloride and the organic layer evaporated to dryness. The yellow oil is triturated with ether to obtain 8-(p-chlorophenylsulfonamido)-4-[2-(1-imidazolyl)ethyl]-octanoic acid as a crystalline solid, NMR (CDCl3): delta 7.82 (d,2H), 7.45 (d,2H), 4.15 (m,2H), 2.35 (t,2H).

후처리

  1. temperatureThe mixture is heated at 50° for 4 hours
  2. customthe solvent is evaporated
  3. customThe residue is triturated with methylene chloride
  4. customthe organic layer evaporated to dryness
  5. customThe yellow oil is triturated with ether

출처 및 근거

ORD 기록
ord-ffab3a03c40143f8bc2d89bf62f2af0f
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05025025

반응 노트

불러오는 중…