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Water → 4-Chloro-1-nitro-2-phenoxybenzene

HRID 1496958
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인쇄 미리보기

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HRID 1496958 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4](F)[CH:3]=1.[C:12]1([OH:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+].O>CS(C)=O.C(OCC)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:18][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 962WaterHCID 996PhenolHCID 11430Potassium CarbonateHCID 696914-Chloro-2-fluoro-1-nitrobenzene

생성물 1

HCID 122900444-Chloro-1-nitro-2-phenoxybenzene

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매
HCID 3283
Diethyl Ether
용매

실험 절차

4-chloro-2-fluoro-nitrobenzene (500 mg), phenol (270 mg), and potassium carbonate (400 mg) were dissolved in dimethyl sulfoxide (10 ml), and stirred at room temperature for 2 hours. The mixture was added with water and ethyl ether to extract an organic layer. The resulting organic layer was washed with saturated brine, and water was removed with sodium sulfate, and the solvent was removed by distillation under reduced pressure. The yellow target compound obtained by removing the solvent was used in the subsequent reaction without further purification (500 mg).

후처리

  1. extractionto extract an organic layer
  2. washThe resulting organic layer was washed with saturated brine, and water
  3. customwas removed with sodium sulfate
  4. customthe solvent was removed by distillation under reduced pressure
  5. customThe yellow target compound obtained
  6. customby removing the solvent
  7. customwas used in the subsequent reaction without further purification (500 mg)

출처 및 근거

ORD 기록
ord-0ab8e1930a96477aa8d4a839d683cd10
출처 데이터셋
uspto-grants-2015_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09199944B2

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