N-bromobutanimide → (2-Amino-5-bromophenyl)(4-chlorophenyl)methanone

HRID 1497712

반응식

HRID 1497712 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)=[O:9].C1C(=O)N([Br:24])C(=O)C1>C(Cl)Cl>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:24])=[CH:4][C:3]=1[C:8]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)=[O:9]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 761662-Amino-4'-chlorobenzophenone

생성물 1

HCID 182477(2-Amino-5-bromophenyl)(4-chlorophenyl)methanone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (2-Amino-phenyl)-(4-chloro-phenyl)-methanone (9.41 g, 0.04 mmol) dissolved in 150 mL DCM was added NBS (7.25 g, 0.04mol) at 0° C. The mixture is stirred at RT for overnight. The mixture is extracted with DCM, washed with NaHCO3, dried over NaSO4 and concentrated. This provides the desired compound. This is used without further purification.

후처리

  1. extractionThe mixture is extracted with DCM
  2. washwashed with NaHCO3
  3. dry with materialdried over NaSO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7e3a8be07b7c4d17aec8283a2b9f3b27
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09199988B2

연결된 노트

불러오는 중…