Hydrochloric Acid → 6-(2,6-Difluorophenyl)-5-fluoropicolinic acid

HRID 1499430노트

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HRID 1499430 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[N:14]=[C:13]([C:15]([O:17]C)=[O:16])[CH:12]=[CH:11][C:10]=1[F:19].O.[OH-].[Li+].C1COCC1.Cl>O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[N:14]=[C:13]([C:15]([OH:17])=[O:16])[CH:12]=[CH:11][C:10]=1[F:19]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 168937Lithium hydroxide, monohydrateHCID 86726680Methyl 6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxylate

생성물 1

HCID 592265526-(2,6-Difluorophenyl)-5-fluoropicolinic acid수율 81.4%

시약·촉매·용매 1

HCID 962Water용매2회

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온도
50 °C

실험 절차

To a mixture of methyl 6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxylate (210.2 mg, 0.7867 mmol) and lithium hydroxide, monohydrate (162 mg, 3.86 mmol), THF (3.0 mL) was added followed by water (1.0 mL). The mixture was heated at 50° C. for 3 h. The reaction mixture was then cooled to 0° C., and 1 M HCl was added slowly until the pH reached 2. The reaction mixture was then diluted with water (20 mL), extracted with EtOAc (3×20 mL) and the combined organic layers were washed with brine (30 mL), dried over Na2SO4, and concentrated under reduced pressure to yield the sub-title compound as a white solid (162.1 mg, 81%). LCMS calc. for C12H7F3NO2 (M+H)+: m/z=254.0. found 254.0.

후처리

  1. additionwas added
  2. temperatureThe reaction mixture was then cooled to 0° C.
  3. extractionextracted with EtOAc (3×20 mL)
  4. washthe combined organic layers were washed with brine (30 mL)
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b483b9c788c74761aee82fcbff43e186
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09200004B2

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