2-Aminophenol → 4-(Aminophenoxy)quinazoline

HRID 1500204

반응식

HRID 1500204 반응식
[NH2:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[CH:7]C=1.[NH2:19]C1C=CC=CC=1O.ClC1C2C(=CC=CC=2)N=CC=1.[H-].[Na+]>CS(C)=O>[NH2:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[CH:7][N:19]=1

참가 물질

6

반응물 4

HCID 58012-AminophenolHCID 24758Sodium hydrideHCID 691404-ChloroquinolineHCID 218903244-(Aminophenoxy)quinoline

생성물 1

HCID 226371474-(Aminophenoxy)quinazoline

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

Alternatively, the 4-(aminophenoxy)quinoline derivative can be produced by reacting an aminophenol derivative with the 4-chloroquinoline derivative in a suitable solvent, for example, dimethyl sulfoxide, in the presence of a base, for example, sodium hydride. Alternatively, the 4-(aminophenoxy)quinazoline derivative can also be produced by dissolving an aminophenol derivative in an aqueous sodium hydroxide solution and subjecting the solution to a two-phase reaction with a solution of the 4-chloroquinazoline derivative in a suitable organic solvent, for example, ethyl methyl ketone, in the presence of a phase transfer catalyst, for example, tetra-n-butylammonium chloride, or in the absence of a catalyst (Scheme 2).

출처 및 근거

ORD 기록
ord-14a81141ea904ce4a5132d609f55a4e6
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206130B2

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