Hydrochloric Acid → alpha,alpha-Dimethyl-4-(trifluoromethyl)benzenepropanoic acid
반응식
[CH3:1][C:2]([CH3:19])([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1)[C:3]([O:5]CC)=[O:4].[OH-].[Na+].Cl>CO>[CH3:1][C:2]([CH3:19])([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:16])([F:17])[F:18])=[CH:11][CH:10]=1)[C:3]([OH:5])=[O:4]참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
Dissolve ethyl 2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanoate (400 mg, 1.46 mmol) in MeOH (2 mL) and add aqueous NaOH solution (3 mL of 3 N). Heat to 80° C. and stir for 3 h. Cool to ambient temperature and acidify with 1 N HCl until pH 4. Extract with EtOAc. Combine organic extracts, wash with brine, dry over sodium sulfate, filter, and concentrate to give the title compound (272 mg).
후처리
- temperatureCool to ambient temperature
- extractionExtract with EtOAc
- washCombine organic extracts, wash with brine
- dry with materialdry over sodium sulfate
- filtrationfilter
- concentrationconcentrate
출처 및 근거
- ORD 기록
- ord-018241eabb054d13ba718f99114f0494
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09206139B2
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