Hydrochloric Acid → HCID 67369868, 화합물

HRID 1500340노트

반응식

HRID 1500340 반응식
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][C:12]([N:20]([CH3:22])[CH3:21])([C:15]2[S:16][CH:17]=[CH:18][CH:19]=2)[CH2:11][CH2:10]1)=O)(C)(C)C.CCOC(C)=O.CCCCCC>C(Cl)(Cl)Cl>[ClH:1].[ClH:1].[CH3:21][N:20]([CH3:22])[C:12]1([C:15]2[S:16][CH:17]=[CH:18][CH:19]=2)[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 21226206Ethyl acetate hexaneHCID 57831240HCID 57831240, 화합물

생성물 1

HCID 67369868HCID 67369868, 화합물수율 98%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

HCl gas was passed through a solution of 6 g (1 eq) tert-butyloxycarbonyl-4-(dimethylamino)-4-(thiophen-2-yl)piperidine in 120 ml chloroform at 0° C. for 1 h. The reaction course was monitored by thin-layer chromatography (75% EtOAc/hexane). Once the conversion was complete, the solvent was removed under reduced pressure and 5.3 g (98%) of product were obtained in the form of a white solid.

후처리

  1. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-57e3166f03ab4e619e1c27c5e2158a91
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206156B2

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