Acetic Acid → HCID 178503516, 화합물

HRID 1500455노트

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HRID 1500455 반응식
[OH:1][C:2]1[N:7]=[C:6]([SH:8])[N:5]=[C:4]2[NH:9][N:10]=[C:11]([CH3:12])[C:3]=12.[OH-].[Na+].CI.[CH3:17]C(O)=O>O>[OH:1][C:2]1[N:7]=[C:6]([S:8][CH3:17])[N:5]=[C:4]2[NH:9][N:10]=[C:11]([CH3:12])[C:3]=12

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 178434482HCID 178434482, 화합물

생성물 1

HCID 178503516HCID 178503516, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture of 4-hydroxy-6-mercapto-3-methylpyrazolo[3,4-d]pyrimidine (A-1) (2.86 g, 11.8 mmol) and NaOH (0.8 g, 20 mmol) in water (20 mL) at 5° C., was added CH3I (2.0 g, 14.2 mmol). After stirred at ambient temperature for 30 min, the solution was acidified with HOAc to give the crude product of the title compound (A-2), which used in next step without further purification. MS-ESI (m/z): 197.0 (M+H)+.

출처 및 근거

ORD 기록
ord-bdbdf110cbb54d9797f0d4b8d7040e3b
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206166B2

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