Hydrochloric Acid → 1-methyl-6-{3-[N-(1-oxo-1,2-dihydroisoquinolin-4-yl)-N-(pyridin-4-ylmethyl)amino]propoxy}-1H-quinolin-2-one

HRID 1504195노트

반응식

HRID 1504195 반응식
C[O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([N:13]([CH2:21][CH2:22][CH2:23][O:24][C:25]2[CH:26]=[C:27]3[C:32](=[CH:33][CH:34]=2)[N:31]([CH3:35])[C:30](=[O:36])[CH:29]=[CH:28]3)[CH2:14][C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)=[CH:5][N:4]=1.Cl.[OH-].[Na+]>C(O)C>[CH3:35][N:31]1[C:32]2[C:27](=[CH:26][C:25]([O:24][CH2:23][CH2:22][CH2:21][N:13]([C:6]3[C:7]4[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=4)[C:3](=[O:2])[NH:4][CH:5]=3)[CH2:14][C:15]3[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=3)=[CH:34][CH:33]=2)[CH:28]=[CH:29][C:30]1=[O:36]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 867626926-{3-[N-(1-Methoxyisoquinolin-4-yl)-N-(pyridin-4-ylmethyl)amino]propoxy}-1-methyl-1H-quinolin-2-one

생성물 1

HCID 867626911-methyl-6-{3-[N-(1-oxo-1,2-dihydroisoquinolin-4-yl)-N-(pyridin-4-ylmethyl)amino]propoxy}-1H-quinolin-2-one수율 38.6%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
75 °C

실험 절차

6-{3-[N-(1-Methoxyisoquinolin-4-yl)-N-(pyridin-4-ylmethyl)amino]propoxy}-1-methyl-1H-quinolin-2-one (55 mg) was added to a 1N-hydrogen chloride in ethanol solution(5 ml), and stirred at 75° C. for 2 hours. The reaction mixture was cooled to room temperature. 1N-Sodium hydroxide aqueous solution(5 ml) was added to the reaction mixture, followed by extraction with dichloromethane. The organic layer was dried over anhydrous sodium sulfate. The filtrate was condensed under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate: methanol=10:0→4:1). The purified product was condensed under reduced pressure to give the title compound(20.6 mg) as a colorless oil.

후처리

  1. temperatureThe reaction mixture was cooled to room temperature
  2. extractionfollowed by extraction with dichloromethane
  3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  4. customcondensed under reduced pressure
  5. customthe residue was purified by silica gel column chromatography (ethyl acetate: methanol=10:0→4:1)
  6. customcondensed under reduced pressure

출처 및 근거

ORD 기록
ord-fb93a21322b04bb4a6823ae91c06bec5
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09212187B2

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