4-tert-Butylcyclohexanone → 1-[4-(Tert-butyl)-1-cyclohexen-1-YL]pyrrolidine

HRID 1504993

반응식

HRID 1504993 반응식
[C:1]([CH:5]1[CH2:10][CH2:9][C:8](=O)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[NH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1>C1(C)C=CC=CC=1>[C:1]([CH:5]1[CH2:10][CH2:9][C:8]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 73924-tert-ButylcyclohexanoneHCID 31268Pyrrolidine

생성물 1

HCID 1072321-[4-(Tert-butyl)-1-cyclohexen-1-YL]pyrrolidine

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A 50 mL round-bottomed flask containing 4-tert-butylcyclohexanone (6.01 gm) in anhydrous toluene (20 mL) was fitted with a Dean-Stark trap containing 3A molecular sieves, reflux condenser and a heating mantle. Pyrrolidine (6.00 mL) was added, and the solution heated to reflux for 18 hr. The solvent was evaporated and the crude product was used directly for the next reaction.

후처리

  1. customwas fitted with a Dean-Stark trap
  2. temperaturereflux condenser
  3. temperaturethe solution heated
  4. temperatureto reflux for 18 hr
  5. customThe solvent was evaporated
  6. customthe crude product was used directly for the next reaction

출처 및 근거

ORD 기록
ord-bcf3b8f806d74b62bb2d057e7b5ce976
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09216966B2

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