Hydrochloric Acid → HCID 90229449, 화합물
반응식
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH:14]([F:16])[F:15])=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Li+].Cl>CO>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH:14]([F:15])[F:16])=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]참가 물질
5
실험 절차
To a solution of methyl 2-chloro-5-(2,2-difluoroethoxy)benzoate (55 mg) in MeOH (1 mL) was added 1M aqueous lithium hydroxide (0.88 mL), and the solution was stirred at room temperature for 12 hours. The reaction mixture was stirred under ice-cooling, 2M hydrochloric acid was added slowly to acidify to pH 2-3, and the precipitated solid was filtered. The solid was washed sequentially with a small amount of water and diethyl ether, and dried under reduced pressure to obtain the titled compound (28 mg) as white powder.
후처리
- stirringThe reaction mixture was stirred under ice-
- temperaturecooling
- filtrationthe precipitated solid was filtered
- washThe solid was washed sequentially with a small amount of water and diethyl ether
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-1e3bc9f5b08941cf85cbca8f3529e977
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09216968B2
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