4-Methylmorpholine → (2-Bromo-4-nitrophenyl)(pyrrolidin-1-yl)methanone

HRID 15102

반응식

HRID 15102 반응식
[Br:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CN1CCOCC1>CN(C=O)C>[Br:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:6]

참가 물질

6

반응물 4

HCID 79724-MethylmorpholineHCID 31268PyrrolidineHCID 3135342-Bromo-4-nitrobenzoic acidHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

생성물 1

HCID 68637791(2-Bromo-4-nitrophenyl)(pyrrolidin-1-yl)methanone

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Prepared analogously to Example 1a from 2-bromo-4-nitro-benzoic acid and pyrrolidine with TBTU and NMM in DMF.

출처 및 근거

ORD 기록
ord-1048e2e281ec483fb3412695eaac9f3d
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732466B2

연결된 노트

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