Hydrochloric Acid → 2,6-Dibromo-3-pyridinecarboxylic acid

HRID 1512976노트

반응식

HRID 1512976 반응식
[Br:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][CH:5]=[C:4]([Br:10])[N:3]=1.P([O-])(O)(O)=[O:12].[Na+].CC(=CC)C.Cl([O-])=O.[Na+].Cl>C(O)(C)(C)C.O>[Br:1][C:2]1[N:3]=[C:4]([Br:10])[CH:5]=[CH:6][C:7]=1[C:8]([OH:12])=[O:9]

참가 물질

8

반응물 5

HCID 313Hydrochloric AcidHCID 105532-Methyl-2-buteneHCID 122593842,6-Dibromopyridine-3-carbaldehydeHCID 23668197Sodium ChloriteHCID 23672064Monosodium phosphate

생성물 1

HCID 122593872,6-Dibromo-3-pyridinecarboxylic acid수율 88%

시약·촉매·용매 2

HCID 962Water용매3회HCID 6386tert-Butanol용매

실험 절차

To a solution of 2,6-dibromo-3-formylpyridine (0.3 g) in tert-butanol (12 mL)-water (1 mL) were added sodium dihydrogen phosphate (0.14 g), 2-methyl-2-butene (0.32 g) and a solution of sodium chlorite (0.36 g) in water (2 mL) successively at room temperature, and the mixture was stirred for 2 hours. The reaction mixture was poured into water. The mixture was acidified by adding 1 mol/L hydrochloric acid, and the resulting mixture was extracted with ethyl acetate. The extract was washed with water, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (0.28 g).

후처리

  1. extractionthe resulting mixture was extracted with ethyl acetate
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-bb873ee1f03747e2a1067c41fa17e7bf
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217069B2

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