4-Hydroxybenzaldehyde → 4-((4-Methylpiperazin-1-yl)methyl)phenol

HRID 1518377

반응식

S1C2C=CC=CC=2N=C1N(COCC[Si](C)(C)C)C(C1C=CC=C2C=1CN(C1SC([CH2:32][N:33]3[CH2:38][CH2:37][N:36](C4C=CC=CC=4)[CH2:35][CH2:34]3)=C(C(OC)=O)N=1)CC2)=O.C1C=CC(N2CCNCC2)=CC=1.[OH:65][C:66]1[CH:73]=[CH:72][C:69]([CH:70]=O)=[CH:68][CH:67]=1.CN1CCNCC1>>[CH3:32][N:33]1[CH2:38][CH2:37][N:36]([CH2:70][C:69]2[CH:72]=[CH:73][C:66]([OH:65])=[CH:67][CH:68]=2)[CH2:35][CH2:34]1

참가 물질

반응물 4

HCID 1264-Hydroxybenzaldehyde

HCID 70961-Phenylpiperazine

HCID 531671-Methylpiperazine

HCID 59447670methyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-((4-phenylpiperazin-1-yl)methyl)thiazole-4-carboxylate

생성물 1

HCID 207061934-((4-Methylpiperazin-1-yl)methyl)phenol

실험 절차

Compound 89A was prepared in a similar manner to the synthesis of compound 62A by substituting compound 45C and phenylpiperazine with 4-hydroxybenzaldehyde and 1-methylpiperazine, respectively: ESI (+)/MS: 207 (M+H)+.

출처 및 근거

ORD 기록: ord-e3a741cdefa44085acc47bce78e24529
출처 데이터셋: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08232273B2

연결된 노트

불러오는 중…