Azobisisobutyronitrile → 5-(Bromomethyl)-4-(4-chlorophenyl)-2-fluoropyridine
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([CH3:14])=[CH:12][N:11]=[C:10]([F:15])[CH:9]=2)=[CH:4][CH:3]=1.[Br:16]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N>C(Cl)(Cl)(Cl)Cl>[Br:16][CH2:14][C:13]1[C:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)=[CH:9][C:10]([F:15])=[N:11][CH:12]=1참가 물질
5
실험 절차
A mixture of EXAMPLE 307A (1.2 g), N-bromosuccinimide (1.06 g) and AIBN (azobisisobutyronitrile) (0.178 g) in CCl4 (30 mL) was heated under reflux for 6 hours. After cooling, the solid was filtered off. The filtrate was concentrated and loaded onto a silica gel column eluting with 3% ethyl acetate in hexanes to give the title compound.
후처리
- temperatureunder reflux for 6 hours
- temperatureAfter cooling
- filtrationthe solid was filtered off
- concentrationThe filtrate was concentrated
- washeluting with 3% ethyl acetate in hexanes
출처 및 근거
- ORD 기록
- ord-a6c5f8fa96c744ce81060da98efd439b
- 출처 데이터셋
- uspto-grants-2015_07
- 특허 번호
- US09073855B2
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