Hydrochloric Acid → HCID 86686552, 화합물

HRID 1528059노트

반응식

HRID 1528059 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([N:15]2[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16]2)[CH:12]=[CH:11][C:10]=1[N:22]1[CH:27]=[C:26]([O:28][CH3:29])[C:25](=[O:30])[C:24]([C:31]([O:33]C)=[O:32])=[N:23]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].C1COCC1.Cl>CO>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([N:15]2[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16]2)[CH:12]=[CH:11][C:10]=1[N:22]1[CH:27]=[C:26]([O:28][CH3:29])[C:25](=[O:30])[C:24]([C:31]([OH:33])=[O:32])=[N:23]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 86686550HCID 86686550, 화합물

생성물 1

HCID 86686552HCID 86686552, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of methyl 1-[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]-5-methoxy-4-oxo-1,4-dihydropyridazine-3-carboxylate (4.54 g), 1M aqueous sodium hydroxide solution (15 mL), THF (30 mL) and methanol (30 mL) was stirred at room temperature for 30 min. The reaction mixture was neutralized with 1M hydrochloric acid, and the precipitate was collected by filtration, and washed with water to give the title compound (0.5 THF solvate, 4.70 g).

후처리

  1. filtrationthe precipitate was collected by filtration
  2. washwashed with water

출처 및 근거

ORD 기록
ord-ace36f4df843405d85ec159f73e36e40
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09090586B2

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